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Infection and Immunotherapy Research

Organisation profile

Organisation profile

The goal of the Infection and Immunotherapy Research (IIR) is to develop new immunotherapies against infectious diseases and cancer. They aim to provide a new translational understanding on HIV cure, bacterial infections and of cancer immunology. The group is also involved in clinical research working towards the elimination of HIV and Hepatitis in Luxembourg.

 

Aims and objectives

 We focus on the development of immunotherapeutic complexes and NK cell engagers boosting innate immunity against viruses, bacteria and cancer cells for further elimination by the immune system.  Our research encompasses protein engineering, virology, bacteriology, immunoassays and preclinical studies for the design of targeted therapeutic approaches.

 

HIV and viral hepatitis elimination

Our group support the monitoring of HIV and Hepatitis elimination in Luxembourg, as part of international research and surveillance networks, through outreach projects and clinical studies from the national HIV and Hepatitis programmes.

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Collaborations and top research areas from the last five years

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  • Assessment of NK cell cytotoxicity induced by IL-15 based immunotherapy against cancer cells

    Rolin, C., Iserentant, G., Pitiot, A. & Seguin-Devaux, C., 17 Apr 2026, Advanced Methodologies to Study and Enhance Cellular Cytotoxicity Against Cancer. Thomas, C. & Galluzzi, L. (eds.). Academic Press Inc., p. 203-218 16 p. (Methods in Cell Biology; vol. 207).

    Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

  • Global and regional molecular epidemiology of HIV-1 during 1990–2024: systematic review, global survey, and analysis of prevalence

    Khalid, A., Gettins, L., Scullion, L., Liu, X., Lin Wei, L. L., Masai, A. N., Guerin, P. J., Allel, K., Hemelaar, J., Abidi, S. H., Abimiku, A. G., Agwale, S., Archibald, C., Avidor, B., Ávila-Ríos, S., Áy, É., Ba, A. A., Barbás, M. G., Barre-Sinoussi, F. & Barugahare, B. & 161 others, Bbosa, N., Belabbes, E. H., Bezemer, D., Bobkov, A. F., Brandful, J., Bredell, H., Brennan, C. A., Brooks, J., Bruckova, M., Buonaguro, F., Buonaguro, L., Buttò, S., Buve, A., Carrera, A., Carrillo, M. G., Charles, M., Chatzidimitriou, D., Chehadeh, W., Cooper, D., Cunningham, P., Dagnra, A., De Francesco, M. A., Dean, J., Del Amo, J., Dietrich, U., Diop-Ndiaye, H., Dwyer, D., Ellenberger, D., Ensoli, B., Essex, M., Fall, M., Featherstone, L. A., Fleury, H., Fonjungo, P. N., Foulongne, V., Fraser, C., Gadkari, D. A., Gao, F., García, F., Gershy-Damet, G. M., Glynn, J. R., Grabowski, M. K., Grossman, Z., Guimarães, M., Hahn, B., Handema, R., He, X., Hemalatha, H., Ho, D. D., Holguín, A., Hosseinipour, M., Hunt, G., Huo, Y., Ito, M., Izopet, J., Jesus, C. S., Kaleebu, P., Kalish, M., Kamori, D., Kang, C., Kanki, P., Karamov, E., Karasi, J. C., Kayitenkore, K., Kelleher, A., Kirichenko, A., Kitayaporn, D., Kostrikis, L. G., Kucherer, C., Lara, C., Leitner, T., Leye, N., Liitsola, K., Lingappa, J., Linka, M., Loosli, T., Lorenzana de Rivera, I., Lukashov, V., Luke Elizabeth, H., Maggiorella, M. T., Manga, P., McCutchan, F., Meda, N., Memarnejadian, A., Menu, E., Mhalu, F., Mloka, D., Mokili, J. L., Molès, J. P., Montès, B., Monzani, C., Mor, O., Morgado, M. G., Mosha, F., Moussi, A., Moyo, S., Mullins, J., Najera, R., Ndembi, N., Neilson, J. R., Nerurkar, V. R., Nesakumar, M., Neuhann, F., Novitsky, V., Nyambi, P., Ofner, M., Paladin, F. J., Papa, A., Papadimitriou, E., Peeters, M., Pelletier, A., Pillay, D., Quang, T. D., Raikanikoda, F., Ranga, U., Raymond, S., Reynes, J. M., Robbins, K. E., Salazar-Gonzales, J., Salminen, M., Salomon, H., Sarker, M. S., Sarr, A. D., Sayan, M., Schroeder, B., Segondy, M., Sempala, S., Servais, J., Shao, Y., Simona, P., Soares, M. A., Songok, E., Ssemwanga, D., Stefani, M., Subbarao, S., Sutthent, R., Takehisa, J., Tanuri, A., Taveira, N., Tee, K. K., Thomson, M., Toure-Kane, C., Turk, G., Urassa, W., van de Perre, P., van der Groen, G., van der Valk, M., Van Laethem, K., van Oosterhout, J., van Sighem, A., Vellas, C., Vidal, N., Wallace, L., Williamson, C., Wolday, D., Xu, J., Yabar Varas, C. A., Yang, C., Zevallos, G. F. V., Zhang, L. & Zhang, R., Sept 2026, In: The Lancet Infectious Diseases. 26, 9, p. 939-955 17 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    1 Citation (Scopus)

  • immunoHuMiX: A personalizable gut-on-chip model for unraveling human microbiome–immune interactions

    De Rudder, C., Greenhalgh, K., Baginska, J., Martin-Gallausiaux, C., Grandmougin, L., Villette, R., Lucchetti, M., Hansen, B., Ostaszewski, M., Petrov, V. A., Atarashi, K., Weidert, L., Frachet Bour, A., Ternes, D., Ramiro-Garcia, J., Malabirade, A., Tanoue, T., Mac Giolla Eain, M., Letellier, E. & Barrett, M. & 7 others, Lacombe, J., Zenhausern, F., Guérin, C., Ollert, M., Seguin-Devaux, C., Honda, K. & Wilmes, P., 24 Mar 2026, In: VIEW. 16 p.

    Research output: Contribution to journal › Article › Research › peer-review

    Open Access
    1 Citation (Scopus)
View all 209 research outputs