Organisation profile
Organisation profile
The goal of the Infection and Immunotherapy Research (IIR) is to develop new immunotherapies against infectious diseases and cancer. They aim to provide a new translational understanding on HIV cure, bacterial infections and of cancer immunology. The group is also involved in clinical research working towards the elimination of HIV and Hepatitis in Luxembourg.
Aims and objectives
We focus on the development of immunotherapeutic complexes and NK cell engagers boosting innate immunity against viruses, bacteria and cancer cells for further elimination by the immune system. Our research encompasses protein engineering, virology, bacteriology, immunoassays and preclinical studies for the design of targeted therapeutic approaches.
HIV and viral hepatitis elimination
Our group support the monitoring of HIV and Hepatitis elimination in Luxembourg, as part of international research and surveillance networks, through outreach projects and clinical studies from the national HIV and Hepatitis programmes.
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Collaborations and top research areas from the last five years
Profiles
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MICRO-PATH (Victoria Barros): Multimeric complexes to unlock the therapeutic potential of innate immunity against chronic respiratory infections
Seguin-Devaux, C. (PI) & Barros, V. (PhD Student)
FNR - Fonds National de la Recherche
1/10/25 → 30/09/29
Project: Research
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PDAC-ORGA: Harnessing NK cells and Graphene Oxide Nanoparticles for Pancreatic Ductal Adenocarcinoma Immunotherapy
Seguin-Devaux, C. (PI)
1/09/25 → 30/11/29
Project: Research
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PSEUDO: Pre-clinical validation of CoMiX and Bikes/Trikes against infections with Pseudomonas aeruginosa
Seguin-Devaux, C. (PI), Zimmer, J. (Partner), Si-Tahar, M. (Partner) & Pitiot, A. (Partner)
FNR - Fonds National de la Recherche
1/02/23 → 30/04/26
Project: Research
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Assessment of NK cell cytotoxicity induced by IL-15 based immunotherapy against cancer cells
Rolin, C., Iserentant, G., Pitiot, A. & Seguin-Devaux, C., 17 Apr 2026, Methods in Cell Biology. Academic Press Inc., (Methods in Cell Biology).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
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immunoHuMiX: A personalizable gut-on-chip model for unraveling human microbiome–immune interactions
De Rudder, C., Greenhalgh, K., Baginska, J., Martin-Gallausiaux, C., Grandmougin, L., Villette, R., Lucchetti, M., Hansen, B., Ostaszewski, M., Petrov, V. A., Atarashi, K., Weidert, L., Frachet Bour, A., Ternes, D., Ramiro-Garcia, J., Malabirade, A., Tanoue, T., Mac Giolla Eain, M., Letellier, E. & Barrett, M. & 7 others, , 24 Mar 2026, In: VIEW. 16 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Co-occurrence of memory impairment and fatigue distinguishes post COVID from pandemic-related health effects in the 4-year CON-VINCE cohort study
Bulaev, D., Rauschenberger, A., Fritz, J. V., Tsurkalenko, O., Kolodkin, A., Vaillant, M., Klucken, J., Krüger, R., Lorentz, V., Bocquet, V., Mtimet, S., Roland, O., Kofanova, O., Aouali, N., Menster, M., Alexandre, M., Valenti, M., Richard, I., Marques, G. & Contesotto, G. & 72 others, , 27 Oct 2025, In: Scientific Reports. 15, 1, 14 p., 37381.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus)