Organisation profile
Organisation profile
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
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Collaborations and top research areas from the last five years
Profiles
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ACKROS: Atypical Chemokine Receptors in the Regulation of the Opioid System and Pain Signaling
Szpakowska, M. (PI)
FNR - Fonds National de la Recherche
1/04/26 → 31/03/29
Project: Research
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NanoLux: NanoLux Platform Mobility to Quebec
Chevigne, A. (CoPI) & Szpakowska, M. (CoPI)
1/09/24 → 31/08/27
Project: Research
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IMPACTT: Identifying Molecular Patterns of Atypical Chemokine Receptors for Translational Targeting
Szpakowska, M. (PI) & Chevigne, A. (Scientific Advisor/Mentor)
Collaboration Fondation Cancer - FNR
1/01/24 → 31/03/27
Project: Research
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Regulation of the orphan G-protein–coupled receptor GPRC5B by MLC1 and the cell adhesion molecule GlialCAM in megalencephalic leukoencephalopathy
Pont-Espinós, G., Pla-Casillanis, A., Ferigle, L., Alonso-Gardón, M., González-Subías, M., Elorza-Vidal, X., Gaitán-Peñas, H., Errasti-Murugarren, E., Chevigne, A., López-Hernández, T., Ciruela, F. & Estévez, R., Jan 2026, In: Journal of Biological Chemistry. 302, 1, 110987.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Retinal determination network reactivation drives chemoresistance and blocks myeloid differentiation in acute myeloid leukemia
Clayfield, L., Malik, D., Whittle, J., Xu, J., Mevel, R., Fadlullah, M. Z. H., Patel, R., Szpakowska, M., Maqbool, M. A., Jones, M., Lie-A-Ling, M., Chevigne, A., Paggetti, J., Moussay, E., Baker, S. M., Iqbal, M., Maire, P., Somervaille, T. C. P., Ford, H. L. & Kouskoff, V. & 2 others, , 24 Feb 2026, In: Cell Reports. 45, 2, 30 p., 116875.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Biased antagonism of a series of bicyclic CXCR2 intracellular allosteric modulators
Van Bosstraeten, B., Boon, K., Van Hoof, M., Dehaen, W., Szpakowska, M., Chevigné, A., Schols, D., De Jonghe, S. & Van Loy, T., 14 Jul 2025, In: Frontiers in Pharmacology. 16, 10 p., 1631129.Research output: Contribution to journal › Article › Research › peer-review
Open Access