Projects per year
Organisation profile
Organisation profile
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
Fingerprint
Dive into the research topics where Immuno-Pharmacology and Interactomics is active. These topic labels come from the works of this organisation's members. Together they form a unique fingerprint.
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Profiles
-
NanoLux: NanoLux Platform Mobility to Quebec
Chevigne, A. (CoPI) & Szpakowska, M. (CoPI)
1/09/24 → 31/08/27
Project: Research
-
IMPACTT: Identifying Molecular Patterns of Atypical Chemokine Receptors for Translational Targeting
Szpakowska, M. (PI) & Chevigne, A. (Scientific Advisor/Mentor)
Collaboration Fondation Cancer - FNR
1/01/24 → 31/03/27
Project: Research
-
CANBIO2 (Joy Darcis): Targeting the atypical chemokine receptor ACKR3 for improved cancer therapy
Chevigne, A. (PI) & Darcis, J. (PhD Student)
FNR - Fonds National de la Recherche
15/10/23 → 14/10/27
Project: Research
-
Design, Synthesis and Pharmacological Characterization of the First Photoswitchable Small-Molecule Agonist for the Atypical Chemokine Receptor 3
Bérenger, S., Adamska, J. M., Deflorian, F., de Graaf, C., Palmer, C. B., Szpakowska, M., Chevigné, A., de Esch, I. J. P., Zarzycka, B., Vischer, H. F., Wijtmans, M. & Leurs, R., 4 Mar 2025, In: ACS Omega. 10, 8, p. 8675-8686 12 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Encoding and decoding selectivity and promiscuity in the human chemokine-GPCR interaction network
Kleist, A. B., Szpakowska, M., Talbot, L. J., Slodkowicz, G., Malinverni, D., Thomas, M. A., Crawford, K. S., McGrail, D. J., Dishman, A. F., Wedemeyer, M. J., Sluter, M., Yi, S. S., Sahni, N., Peterson, F. C., Chevigné, A., Volkman, B. F. & Babu, M. M., 21 Apr 2025, (E-pub ahead of print) In: Cell. 48 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
High-affinity ELR+ chemokine ligands show G protein bias over β-arrestin recruitment and receptor internalization in CXCR1 signaling
Boon, K., Vanalken, N., Szpakowska, M., Chevigné, A., Schols, D. & Van Loy, T., Jan 2025, In: Journal of Biological Chemistry. 301, 1, 11 p., 108044.Research output: Contribution to journal › Article › Research › peer-review
Open Access