Projects per year
Organization profile
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
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Profiles
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MEGAKINE: Megakines - novel tools for structural insight into receptor:chemokine complexes
1/09/21 → 31/08/23
Project: Research
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Atypical opioid receptors: unconventional biology and therapeutic opportunities
Palmer, C. B., Meyrath, M., Canals, M., Kostenis, E., Chevigné, A. & Szpakowska, M., May 2022, In: Pharmacology and Therapeutics. 233, 108014.Research output: Contribution to journal › Review article › peer-review
Open Access5 Citations (Scopus) -
Nanoluciferase-based complementation assay for systematic profiling of GPCR–GRK interactions
Palmer, C. B., D'Uonnolo, G., Luís, R., Meyrath, M., Uchański, T., Chevigné, A. & Szpakowska, M., Jun 2022, In: Methods in Cell Biology. 169, p. 309-321 13 p.Research output: Contribution to journal › Article › peer-review
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Nanoluciferase-based methods to monitor activation, modulation and trafficking of atypical chemokine receptors
Luís, R., D'Uonnolo, G., Palmer, C. B., Meyrath, M., Uchański, T., Wantz, M., Rogister, B., Janji, B., Chevigné, A. & Szpakowska, M., 2022, In: Methods in Cell Biology. 169, p. 279-294 16 p.Research output: Contribution to journal › Article › peer-review