Projects per year
Organisation profile
Organisation profile
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
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Collaborations and top research areas from the last five years
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Profiles
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HOPE-IOID: Multilevel regulation and modulation of the new opioid peptide scavenger ACKR3
1/03/23 → 28/02/27
Project: Research
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Cannabidiol negatively modulates adenosine A2A receptor functioning in living cells
Sánchez-Fernández, N., Gómez-Acero, L., Sarasola, L. I., Argerich, J., Chevigné, A., Jacobson, K. A., Ciruela, F., Fernández-Dueñas, V. & Aso, E., 22 Aug 2023, (E-pub ahead of print) In: Acta Neuropsychiatrica. p. 1-5 5 p.Research output: Contribution to journal › Article › Research › peer-review
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Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
Gray, A. L., Karlsson, R., Roberts, A. R. E., Ridley, A. J. L., Pun, N., Khan, B., Lawless, C., Luís, R., Szpakowska, M., Chevigné, A., Hughes, C. E., Medina-Ruiz, L., Birchenough, H. L., Mulholland, I. Z., Salanga, C. L., Yates, E. A., Turnbull, J. E., Handel, T. M., Graham, G. J., Jowitt, T. A., & 4 others, 31 Jan 2023, In: Cell Reports. 42, 1, 111930.Research output: Contribution to journal › Article › Research › peer-review
Open Access3 Citations (Scopus) -
Formate promotes invasion and metastasis in reliance on lipid metabolism
Delbrouck, C., Kiweler, N., Chen, O., Pozdeev, V. I., Haase, L., Neises, L., Oudin, A., Fouquier d'Hérouël, A., Shen, R., Schlicker, L., Halder, R., Lesur, A., Schuster, A., Lorenz, N. I., Jaeger, C., Feucherolles, M., Frache, G., Szpakowska, M., Chevigne, A., Ronellenfitsch, M. W., & 7 others, 26 Sept 2023, In: Cell Reports. 42, 9, 113034.Research output: Contribution to journal › Article › Research › peer-review
Open Access