Projects per year
Organization profile
Altered cellular signalling and immune dysregulation are hallmarks of most auto-immune, inflammatory and chronic viral diseases. The expression, signalling and activity of chemokines and IFN are often altered in these pathologies but the molecular mechanisms and fine regulation at play are not completely understood. Most viruses have evolved strategies to hijack, bypass or lure these signal transducers and cellular effectors to favour their replication and/or to corrupt or evade immunity.
Our research interests revolve around two axes:
- Fundamental research aiming at gaining new insights into the complex structural and cellular mechanisms that lead to altered cellular signalling and cell transformation.
- Translational research aiming at developing novel tools and therapeutic approaches to interfere or modulate these processes and viral replication.
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Profiles
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ACKR3/CXCL12 axis in GBM: Study of the CXCL12-CXCR4/ACKR3 signaling in glioblastoma and of its importance in the control of translation and relapses
Chevigne, A. & Rogister, B.
FNR - Fonds National de la Recherche
3/05/21 → 30/05/25
Project: Research
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Atypical opioid receptors: unconventional biology and therapeutic opportunities
Palmer, C. B., Meyrath, M., Canals, M., Kostenis, E., Chevigné, A. & Szpakowska, M., May 2022, In: Pharmacology and Therapeutics. 233, 108014.Research output: Contribution to journal › Review article › peer-review
Open Access8 Citations (Scopus) -
Computationally designed GPCR quaternary structures bias signaling pathway activation
Paradis, J. S., Feng, X., Murat, B., Jefferson, R. E., Sokrat, B., Szpakowska, M., Hogue, M., Bergkamp, N. D., Heydenreich, F. M., Smit, M. J., Chevigné, A., Bouvier, M. & Barth, P., 11 Nov 2022, In: Nature Communications. 13, 1, 6826.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Conformational selection guides β-arrestin recruitment at a biased G protein–coupled receptor
Kleist, A. B., Jenjak, S., Sente, A., Laskowski, L. J., Szpakowska, M., Calkins, M. M., Anderson, E. I., McNally, L. M., Heukers, R., Bobkov, V., Peterson, F. C., Thomas, M. A., Chevigné, A., Smit, M. J., McCorvy, J. D., Babu, M. M. & Volkman, B. F., 8 Jul 2022, In: Science. 377, 6602, p. 222-228 7 p.Research output: Contribution to journal › Article › Research › peer-review
2 Citations (Scopus)