Projects per year
The HIV Clinical and Translational Research (HIV-CTR) Group emerged from the Reference Laboratory of Retrovirology offering specialized technical support for the clinical follow-up of HIV and HCV-infected patients in Luxembourg since 1990. The group joined the Department of Infection and Immunity under the direction of Dr Carole Seguin-Devaux, and lead HIV clinical research in the field of resistance to antiviral therapy, transmission, molecular epidemiology and HIV Cure since 2014.
The HIV-CTR research team:
- Provides new translational knowledge on HIV cure and in immunology.
- Develop immunotherapeutic complexes boosting complement or NK cells activation against viruses, bacteria or cancer cells for further elimination by the immune system.
- Since the beginning of the COVID-19 epidemic, the group has developed SARS-CoV-2 cultures and HIV-pseudotypes/viral neutralisation assays for SARS-CoV-2 to assess the potency of antivirals and neutralizing antibodies, respectively.
The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in Sub-Saharian African countries to support knowledge and technology transfer for the clinical management of HIV and hepatitis-infected patients.
Collaborations and top research areas from the last five years
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PSEUDO: Pre-clinical validation of CoMiX and Bikes/Trikes against infections with Pseudomonas aeruginosa
1/02/23 → 31/01/26
1/01/22 → 31/12/23
Pirkl, M., Büch, J., Devaux, C., Böhm, M., Sönnerborg, A., Incardona, F., Abecasis, A., Vandamme, A-M., Zazzi, M., Kaiser, R., Lengauer, T. & The EuResist Network Study Group, Jan 2023, In: Journal of Medical Virology. 95, 1, e28389.
Research output: Contribution to journal › Article › Research › peer-review
Cohort Profile: A European Multidisciplinary Network for the Fight against HIV Drug Resistance (EuResist Network)Rossetti, B., Incardona, F., Di Teodoro, G., Mommo, C., Saladini, F., Kaiser, R., Sönnerborg, A., Lengauer, T., Zazzi, M., EuResist Network, INTEGRATE study group & Seguin-Devaux, C., 23 Apr 2023, In: Tropical Medicine and Infectious Disease. 8, 5, 243.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Dervillez, X., Schober, R., Brandus, B., Seguin-Devaux, C., Zimmer, J. & Cohen, J., 12 Jan 2023, IPC No. C07K14/21; C07K14/47; C07K14/705; C07K14/715; C07K16/00, Patent No. WO2023281120A1, Priority date 9 Jul 2021, Priority No. EP21184691A·2021-07-09
Research output: PatentOpen Access