Organization profile

The HIV Clinical and Translational Research (HIV-CTR) Group emerged from the Reference Laboratory of Retrovirology offering specialized technical support for the clinical follow-up of HIV and HCV-infected patients in Luxembourg since 1990. The group joined the Department of Infection and Immunity under the direction of  Dr Carole Seguin-Devaux, and lead HIV clinical research in the field of resistance to antiviral therapy, transmission, molecular epidemiology and HIV Cure since 2014. 

The HIV-CTR research team: 

  • Provides new translational knowledge on HIV cure and in immunology. 
  • Develop immunotherapeutic complexes boosting complement or NK cells activation against viruses, bacteria or cancer cells for further elimination by the immune system. 
  • Since the beginning of the COVID-19 epidemic, the group has developed SARS-CoV-2 cultures and HIV-pseudotypes/viral neutralisation assays for SARS-CoV-2 to assess the potency of antivirals and neutralizing antibodies, respectively. 

The Group is a partner in several European HIV and HCV networks, collaborates with lifescience and biotech companies, and has built up a network in Sub-Saharian African countries to support knowledge and technology transfer for the clinical management of HIV and hepatitis-infected patients.  

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  • Analysis of the Origin and Dissemination of HIV-1 Subtype C in Bulgaria

    Alexiev, I., Mavian, C., Paisie, T., Ciccozzi, M., Dimitrova, R., Gancheva, A., Kostadinova, A., Seguin-Devaux, C. & Salemi, M., 27 Jan 2022, In: Viruses. 14, 2, 263.

    Research output: Contribution to journalArticlepeer-review

    Open Access
  • Effectiveness of integrase strand transfer inhibitors in HIV-infected treatment-experienced individuals across Europe

    Rossetti, B., Fabbiani, M., Di Carlo, D., Incardona, F., Abecasis, A., Gomes, P., Geretti, A. M., Seguin-Devaux, C., Garcia, F., Kaiser, R., Modica, S., Shallvari, A., Sönnerborg, A., Zazzi, M. & EuResist Network, INTEGRATE study group, 24 Feb 2022, (E-pub ahead of print) In: HIV Medicine.

    Research output: Contribution to journalArticlepeer-review

  • Global change in hepatitis C virus prevalence and cascade of care between 2015 and 2020: a modelling study

    Blach, S., Terrault, N. A., Tacke, F., Gamkrelidze, I., Craxi, A., Tanaka, J., Waked, I., Dore, G. J., Abbas, Z., Abdallah, A. R., Abdulla, M., Aghemo, A., Aho, I., Akarca, U. S., Alalwan, A. M., Alanko Blomé, M., Al-Busafi, S. A., Aleman, S., Alghamdi, A. S., Al-Hamoudi, W. K. & 31 others, Aljumah, A. A., Al-Naamani, K., Al Serkal, Y. M., Altraif, I. H., Anand, A. C., Anderson, M., Andersson, M. I., Athanasakis, K., Baatarkhuu, O., Bakieva, S. R., Ben-Ari, Z., Bessone, F., Biondi, M. J., Bizri, A. R. N., Brandão-Mello, C. E., Brigida, K., Brown, K. A., Brown, R. S., Bruggmann, P., Brunetto, M. R., Busschots, D., Buti, M., Butsashvili, M., Cabezas, J., Chae, C., Chaloska Ivanova, V., Chan, H. L. Y., Cheinquer, H., Cheng, K. J., Seguin-Devaux, C. & The Polaris Observatory HCV Collaborators, May 2022, In: The Lancet Gastroenterology and Hepatology. 7, 5, p. 396-415 20 p.

    Research output: Contribution to journalArticlepeer-review

    4 Citations (Scopus)