Projects per year
Organisation profile
Organisation profile
The Brenner laboratory is strongly dedicated to cutting-edge research. As such, our group combines metabolic, molecular, cellular, and physiological approaches to unravel new ways to control immunity. Our vision is to develop new concepts for personalised medicine to mitigate inflammatory diseases through a mechanism-centered approach. As such, our group promotes a concept in which diseases are not treated based on symptoms, but on their mechanistic and individual cause.
The immune system is crucial for a health body function and protects us from severe infection. However, dysregulated immunity can cause inflammation, autoimmune diseases and cancer. Specifically, the control of immune cell metabolism as emerged as a powerful way to regulate immunity. The Brenner laboratory investigates the metabolic regulation of the immune system and how this ensures a coordinated immune response and homeostasis. We seek to define the molecular, metabolic and cellular processes of inflammation and integrate in vitro with in vivo studies to gain a comprehensive picture of inflammation and cancer. A key aspect and focus of all our projects is the identification of novel metabolic checkpoints that influence the regulation of the immune system. One of these key circuits is the regulation of redox metabolism and reactive oxygen species (ROS) in immune cells. We investigate physiological consequences of ROS accumulation and their impact on immune cell function in health and disease.
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Collaborations and top research areas from the last five years
Profiles
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Dirk Brenner
- Experimental and Molecular Immunology - Group Leader and Deputy Head Research & Strategy, Department of Infection and Immunity
Person: Employee
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Catherine Dostert
- Experimental and Molecular Immunology - Scientist & Member of the Science Strategy Team
Person: Employee
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Nextimmune-2 (Program Management): The Next Generation Immunoscience
1/01/23 → 30/06/29
Project: Research
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PYRAIMD: Deciphering the Function of Mitochondrial Pyruvate Transport in T Cell-Mediated Immunity
1/10/22 → 30/09/24
Project: Research
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A multi-omics integrative approach unravels novel genes and pathways associated with senescence escape after targeted therapy in NRAS mutant melanoma
Gureghian, V., Herbst, H., Kozar, I., Mihajlovic, K., Malod-Dognin, N., Ceddia, G., Angeli, C., Margue, C., Randic, T., Philippidou, D., Nomigni, M. T., Hemedan, A., Tranchevent, L. C., Longworth, J., Bauer, M., Badkas, A., Gaigneaux, A., Muller, A., Ostaszewski, M., Tolle, F., & 2 others , 7 Jul 2023, (E-pub ahead of print) In: Cancer Gene Therapy.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Bonetti, L., Horkova, V., Longworth, J., Guerra, L., Kurniawan, H., Franchina, D. G., Soriano-Baguet, L., Grusdat, M., Spath, S., Koncina, E., Ewen, A., Binsfeld, C., Verschueren, C., Gérardy, J-J., Kobayashi, T., Dostert, C., Farinelle, S., Härm, J., Chen, Y., Harris, I. S., & 7 others , 7 Jul 2023, (bioRxiv).Research output: Working paper › Preprint
Open Access -
Glutathione supports lipid abundance in vivo
Asantewaa, G., Tuttle, E. T., Ward, N. P., Kang, Y. P., Kim, Y., Kavanagh, M. E., Girnius, N., Chen, Y., Duncan, R., Rodriguez, K., Brenner, D. & Harris, I. S., 11 Feb 2023, p. 2023-2022, 2 p. (bioRxiv : the preprint server for biology).Research output: Working paper › Preprint
Open Access