Projects per year
The Brenner laboratory is strongly dedicated to cutting-edge research. As such, our group combines metabolic, molecular, cellular, and physiological approaches to unravel new ways to control immunity. Our vision is to develop new concepts for personalised medicine to mitigate inflammatory diseases through a mechanism-centered approach. As such, our group promotes a concept in which diseases are not treated based on symptoms, but on their mechanistic and individual cause.
The immune system is crucial for a health body function and protects us from severe infection. However, dysregulated immunity can cause inflammation, autoimmune diseases and cancer. Specifically, the control of immune cell metabolism as emerged as a powerful way to regulate immunity. The Brenner laboratory investigates the metabolic regulation of the immune system and how this ensures a coordinated immune response and homeostasis. We seek to define the molecular, metabolic and cellular processes of inflammation and integrate in vitro with in vivo studies to gain a comprehensive picture of inflammation and cancer. A key aspect and focus of all our projects is the identification of novel metabolic checkpoints that influence the regulation of the immune system. One of these key circuits is the regulation of redox metabolism and reactive oxygen species (ROS) in immune cells. We investigate physiological consequences of ROS accumulation and their impact on immune cell function in health and disease.
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1/04/20 → 31/12/21
Kobayashi, T. & Brenner, D., 3 May 2022, In: Cell Metabolism. 34, 5, p. 656-657 2 p.
Research output: Contribution to journal › Comment/debate
Zeng, N., Capelle, C. M., Baron, A., Kobayashi, T., Cire, S., Tslaf, V., Leonard, C., Coowar, D., Koseki, H., Westendorf, A. M., Buer, J., Brenner, D., Krüger, R., Balling, R., Ollert, M. & Hefeng, F. Q., 3 Feb 2022, In: EMBO Reports. 23, 3, p. e53302
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access2 Citations (Scopus)
Glutathione-dependent redox balance characterizes the distinct metabolic properties of follicular and marginal zone B cellsFranchina, D. G., Kurniawan, H., Grusdat, M., Binsfeld, C., Guerra, L., Bonetti, L., Soriano-Baguet, L., Ewen, A., Kobayashi, T., Farinelle, S., Minafra, A. R., Vandamme, N., Carpentier, A., Borgmann, F. K., Jäger, C., Chen, Y., Kleinewietfeld, M., Vasiliou, V., Mittelbronn, M., Hiller, K., & 2 others, 4 Apr 2022, In: Nature Communications. 13, 1, p. 1789 1789.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access1 Citation (Scopus)