Projects per year
Organisation profile
Organisation profile
Beyond their role in preventing genetic instability and tumorigenesis, DNA repair and epigenetic mechanisms also contribute to the resistance of cancer cells to chemotherapeutic genotoxicants. These mechanisms are responsible in great part for the failure of current anti-glioma therapies. The DNA Repair and Chemoresistance research group is developing several approaches to better understand the DNA repair and epigenetic mechanisms that operate in adult and pediatric glioblastoma (GBM) and identify critical targets for novel therapeutic strategies. These approaches include:
- shRNA screens targeting components of the DNA damage response (DDR) in GBM stem-like cell lines (GSCs)
- Multiplexed gene expression analyses of GBM patient biopsies
- In vitro drug repositioning screens of GSCs representative of GBM patient subgroups
- Molecular characterization of the mechanisms underlying DNA replication stress and the DDR in GSCs
- Characterization of relevant xenograft animal models
A second line of investigation explores the molecular mechanisms governing the dynamics of heterochromatic regions and their impact on genomic stability in mammalian cells.
Fingerprint
Collaborations and top research areas from the last five years
Profiles
-
PIANO: Impact of intratumoral heterogeneity on treatment resistance and tumor relapse in glioblastoma
Van Dyck, E. (PI), Mittelbronn, M. (CoPI), Rogister, B. (CoPI), Neirinckx, V. (CoPI) & Torres Fernández, M. (PhD Student)
15/11/23 → 30/11/25
Project: Research
-
CANBIO2 (Ana Catarina Almeida): Harnessing DNA repair factors to promote an innate immune response against glioblastoma
Van Dyck, E. (PI) & Almeida, A. C. (PhD Student)
FNR - Fonds National de la Recherche
1/09/23 → 31/08/27
Project: Research
-
ATLANTIS: Targeting homologous recombination and replication stress in glioblastoma: from molecular insights to synthetic lethality approaches
Van Dyck, E. (PI) & Yi, T. (PhD Student)
FNR - Fonds National de la Recherche
1/03/23 → 28/02/27
Project: Research
-
DAXX promotes centromeric stability independently of ATRX by preventing the accumulation of R-loop-induced DNA double-stranded breaks
Pinto, L. M., Pailas, A., Bondarchenko, M., Sharma, A. B., Neumann, K., Rizzo, A. J., Jeanty, C., Nicot, N., Racca, C., Graham, M. K., Naughton, C., Liu, Y., Chen, C. L., Meakin, P. J., Gilbert, N., Britton, S., Meeker, A. K., Heaphy, C. M., Larminat, F. & Van Dyck, E., 9 Feb 2024, In: Nucleic Acids Research. 52, 3, p. 1136-1155 20 p.Research output: Contribution to journal › Article › Research › peer-review
Open Access2 Citations (Scopus) -
Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity
Scafidi, A., Lind-Holm Mogensen, F., Campus, E., Pailas, A., Neumann, K., Legrave, N., Bernardin, F., Pereira, S. L., Antony, P. M. A., Nicot, N., Mittelbronn, M., Grünewald, A., Nazarov, P. V., Poli, A., Van Dyck, E. & Michelucci, A., 30 Sept 2024, In: Heliyon. 10, 18, e37792.Research output: Contribution to journal › Article › Research › peer-review
Open Access -
Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas: International Journal of Molecular Sciences
Zhang, L., Fritah, S., Nazarov, P. V., Kaoma, T. & Van Dyck, E., 6 Jun 2023, In: International Journal of Molecular Sciences. 24, 12, 9825.Research output: Contribution to journal › Article › Research › peer-review
Open Access