Organisation profile
Organisation profile
DMSP is the result of the collaboration between the Luxembourg Centre for Systems Biomedicine at the University of Luxembourg (LCSB/UL) and LIH. The platform combines the cellular disease modelling expertise of both institutions with early drug discovery technology.
The ultimate objective of the DMSP is to provide a diversity of core facilities infrastructure, disease models and expertise, to facilitate the translation of basic scientific discoveries into tangible hit (drug) candidates. Our state-of-the-art platform acts as interface between fundamental biomedical research and high standard drug discovery:
- to help researchers to develop screenings based on their biological findings
- to perform High Throughput Screenings (HTS) for them with our compounds or their own library
- to develop new cellular disease models for phenotypic screening (HCS)
- to offer phenotypic screenings in established patient-derived cellular models
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Collaborations and top research areas from the last five years
Projects
- 2 Finished
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MelCol_PFP: PERSONAL FUNCTIONAL PROFILING FOR DRUG DISCOVERY IN MELANOMA AND COLORECTAL CANCER
El Khoury, V. (PI), Cutrona, M. (PI) & Kwon, Y.-J. (PI)
FNR - Fonds National de la Recherche
1/04/21 → 30/06/25
Project: Research
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PFP: Personal Functional Profiling
Kwon, Y.-J. (PI), Mao, X. (CoPI) & Michel, T. (Partner)
23/04/18 → 22/04/21
Project: Research
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Co-occurrence of memory impairment and fatigue distinguishes post COVID from pandemic-related health effects in the 4-year CON-VINCE cohort study
Bulaev, D., Rauschenberger, A., Fritz, J. V., Tsurkalenko, O., Kolodkin, A., Vaillant, M., Klucken, J., Krüger, R., Lorentz, V., Bocquet, V., Mtimet, S., Roland, O., Kofanova, O., Aouali, N., Menster, M., Alexandre, M., Valenti, M., Richard, I., Marques, G. & Contesotto, G. & 72 others, , 27 Oct 2025, In: Scientific Reports. 15, 1, 14 p., 37381.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
The role of alpha-synuclein in synucleinopathy: Impact on lipid regulation at mitochondria–ER membranes
Barbuti, P. A., Guardia-Laguarta, C., Yun, T., Chatila, Z. K., Flowers, X., Wong, C., Santos, B. F. R., Larsen, S. B., Lotti, J. S., Hattori, N., Bradshaw, E., Dettmer, U., Fanning, S., Menon, V., Reddy, H., Teich, A. F., Krüger, R., Area-Gomez, E. & Przedborski, S., 30 Apr 2025, In: npj Parkinson's Disease. 11, 1, 15 p., 103.Research output: Contribution to journal › Article › Research › peer-review
Open Access9 Citations (Scopus) -
Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent Glioblastoma
Ratliff, M., Kim, H., Qi, H., Kim, M., Ku, B., Azorin, D. D., Hausmann, D., Khajuria, R. K., Patel, A., Maier, E., Cousin, L., Ogier, A., Sahm, F., Etminan, N., Bunse, L., Winkler, F., El-Khoury, V., Platten, M. & Kwon, Y. J., 12 Jun 2022, In: International Journal of Molecular Sciences. 23, 12, 6572.Research output: Contribution to journal › Article › Research › peer-review
Open Access32 Citations (Scopus)