Projects per year
DMSP is the result of the collaboration between the Luxembourg Centre for Systems Biomedicine at the University of Luxembourg (LCSB/UL) and LIH. The platform combines the cellular disease modelling expertise of both institutions with early drug discovery technology.
The ultimate objective of the DMSP is to provide a diversity of core facilities infrastructure, disease models and expertise, to facilitate the translation of basic scientific discoveries into tangible hit (drug) candidates. Our state-of-the-art platform acts as interface between fundamental biomedical research and high standard drug discovery:
- to help researchers to develop screenings based on their biological findings
- to perform High Throughput Screenings (HTS) for them with our compounds or their own library
- to develop new cellular disease models for phenotypic screening (HCS)
- to offer phenotypic screenings in established patient-derived cellular models
Collaborations and top research areas from the last five years
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Patient-Derived Tumor Organoids for Guidance of Personalized Drug Therapies in Recurrent GlioblastomaRatliff, M., Kim, H., Qi, H., Kim, M., Ku, B., Azorin, D. D., Hausmann, D., Khajuria, R. K., Patel, A., Maier, E., Cousin, L., Ogier, A., Sahm, F., Etminan, N., Bunse, L., Winkler, F., El-Khoury, V., Platten, M. & Kwon, Y. J., 12 Jun 2022, In: International Journal of Molecular Sciences. 23, 12, 6572.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access8 Citations (Scopus)
El-Khoury, V., Michel, T., Kim, H. & Kwon, Y-J., 13 Jun 2022, Elements in Molecular Oncology. Cambridge: Cambridge University Press, (Elements in Molecular Oncology).
Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Personalized functional profiling using ex-vivo patient-derived spheroids points out the potential of an antiangiogenic treatment in a patient with a metastatic lung atypical carcinoidKim, H., El-Khoury, V., Schulte, N., Zhan, T., Betge, J., Cousin, L., Felli, E., Pessaux, P., Ogier, A., Opitz, O., Ku, B., Ebert, M. P. & Kwon, Y. J., 31 Dec 2022, In: Cancer Biology and Therapy. 23, 1, p. 96-102 7 p.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access2 Citations (Scopus)