Projects per year
The Cytoskeleton and Cancer Progression (CCP) research group explores the role of the actin cytoskeleton of tumour cells in two processes that critically promote cancer progression: metastatic spreading and resistance to the immune system, with the ultimate goal of translating its discoveries into clinical applications that benefit patients.
Cancer immune evasion is a major obstacle to effective anticancer immunotherapies and a better understanding of the underlying mechanisms is urgently needed. Using high resolution and quantitative cell imaging approaches, we recently established the pivotal role of the actin cytoskeleton in tumour cell resistance against cytotoxic immune effector cells. Our investigations at the tumour cell side of the immunological synapse (the cell-to-cell contact between cytotoxic lymphocytes cells and tumour cells) open new avenues for the development of innovative therapeutic approaches aimed at restoring an effective antitumor immune response in patients.
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1/10/22 → 30/09/24
Synapodia: Novel synaptic filopodium-like protrusions (SFPs) protect tumor cells against cytotoxic lymphocyte-mediated killing
Thomas, C. & Filali, L.
15/07/22 → 14/08/25
I2TRON Elena Ockfen: Biological and clinical implications of PD-L1 protein polarization at the tumor tissue and cell levels
Thomas, C. & Ockfen, E.
1/03/21 → 28/02/25
Ultrarapid lytic granule release from CTLs activates Ca2+-dependent synaptic resistance pathways in melanoma cellsFilali, L., Puissegur, M. P., Cortacero, K., Cussat-Blanc, S., Khazen, R., Van Acker, N., Frenois, F. X., Abreu, A., Lamant, L., Meyer, N., Vergier, B., Müller, S., McKenzie, B. & Valitutti, S., 18 Feb 2022, In: Science advances. 8, 7, p. eabk3234
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access2 Citations (Scopus)
Ampe, C., al, E., Thomas, C. (ed.) & Galluzzi, L. (ed.), 4 May 2021, 1 ed. Cambridge: Elsevier. 192 p. (International Review of Cell and Molecular Biology; vol. 355)
Research output: Book/Report › Book › peer-review
Wurzer, H., Filali, L. & Thomas, C., Aug 2021, In: PLoS Biology. 19, 8, p. e3001339 e3001339.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access