Projects per year
The Cytoskeleton and Cancer Progression (CCP) research group explores the role of the actin cytoskeleton of tumour cells in two processes that critically promote cancer progression: metastatic spreading and resistance to the immune system, with the ultimate goal of translating its discoveries into clinical applications that benefit patients.
Cancer immune evasion is a major obstacle to effective anticancer immunotherapies and a better understanding of the underlying mechanisms is urgently needed. Using high resolution and quantitative cell imaging approaches, we recently established the pivotal role of the actin cytoskeleton in tumour cell resistance against cytotoxic immune effector cells. Our investigations at the tumour cell side of the immunological synapse (the cell-to-cell contact between cytotoxic lymphocytes cells and tumour cells) open new avenues for the development of innovative therapeutic approaches aimed at restoring an effective antitumor immune response in patients.
Collaborations and top research areas from the last five years
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1/10/22 → 30/09/24
Actin cytoskeleton depolymerization increases matrix metalloproteinase gene expression in breast cancer cells by promoting translocation of cysteine-rich protein 2 to the nucleusMgrditchian, T., Brown-Clay, J., Hoffmann, C., Müller, T., Filali, L., Ockfen, E., Mao, X., Moreau, F., Casellas, C. P., Kaoma, T., Mittelbronn, M. & Thomas, C., 15 May 2023, In: Frontiers in Cell and Developmental Biology. 11, 1100938.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access1 Citation (Scopus)
An integrated workflow for phosphopeptide identification in natural killer cells (NK-92MI) and their targets (MDA-MB-231) during immunological synapse formationPerez-Hernandez, D., Filali, L., Thomas, C. & Dittmar, G., 17 Mar 2023, In: STAR Protocols. 4, 1, 102104.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access
Correlative light and electron microscopy to explore the lytic immunological synapse between natural killer cells and cancer cellsKleine Borgmann, F. B., Hoffmann, C., Carpentier, A., Mittelbronn, M. & Thomas, C., 5 Jun 2023, (Accepted/In press) In: Methods in Cell Biology. 178, p. 96-106
Research output: Contribution to journal › Article › Research › peer-review