Projects per year
Malignant transformation of cells goes along with profound metabolic rewiring to cope with increasing biomass and energy demands. The goal of our research is to understand these metabolic changes pinpointing metabolic bottlenecks that are specific to cancer cells and which, ultimately, might become effective targets for clinical oncotherapy.
To measure the dynamics of cellular metabolism, we make use of stable-isotope tracers and high-resolution Mass Spectrometry. Applying these key tools with molecular and cell biology approaches allows a functional and mechanistic understanding of how metabolism impacts cancer cell proliferation, survival and dissemination. A particular focus resides at understanding the metabolic processes that allow cancer cell motility and invasion, a process essential for the onset of the metastatic cascade. Indeed, metastasis is accountable for 90 % of all cancer deaths. Yet, it remains one of the biggest challenges in cancer therapy and is currently seen as incurable.
An example of our work includes the study of a phenomenon known as “formate overflow”, a metabolic pathway which we have identified to influence cell motility and metastasis.
An additional area of interest is the interaction of cancer cells with their environment. Our work in this respect focuses on immune cells, as they play an important role in shaping either a tumour-promoting or -suppressive environment. Since metabolism plays an important role during immune cell activation, we aim to understand these metabolic dependencies and seek alternative immune cell-dependent entry points to target cancer cells.
Collaborations and top research areas from the last five years
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iNEW: Role for the Itaconate/Nrf2 axis in metabolic and epigenetic reprogramming of neonatal macrophages
Meiser, J. & Ohl, K.
1/03/23 → 31/05/25
1/11/22 → 31/10/24
Author Correction: The gut microbial metabolite formate exacerbates colorectal cancer progression (Nature Metabolism, (2022), 4, 4, (458-475), 10.1038/s42255-022-00558-0)Ternes, D., Tsenkova, M., Pozdeev, V. I., Meyers, M., Koncina, E., Atatri, S., Schmitz, M., Karta, J., Schmoetten, M., Heinken, A., Rodriguez, F., Delbrouck, C., Gaigneaux, A., Ginolhac, A., Nguyen, T. T. D., Grandmougin, L., Frachet-Bour, A., Martin-Gallausiaux, C., Pacheco, M., Neuberger-Castillo, L., & 11 others, 2023, (Accepted/In press) In: Nature Metabolism.
Research output: Contribution to journal › Comment/debateOpen Access
Extracellular Vesicle Secretion by Leukemia Cells In Vivo Promotes CLL Progression by Hampering Antitumor T-cell ResponsesGargiulo, E., Viry, E., Morande, P. E., Largeot, A., Gonder, S., Xian, F., Ioannou, N., Benzarti, M., Borgmann, F. B. K., Mittelbronn, M., Dittmar, G., Nazarov, P. V., Meiser, J., Stamatopoulos, B., Ramsay, A. G., Moussay, E. & Paggetti, J., 6 Jan 2023, In: Blood Cancer Discovery. 4, 1, p. 54-77 24 p.
Research output: Contribution to journal › Article › Research › peer-review7 Citations (Scopus)
Kiweler, N., Chalkiadaki, C., Wiita, E., Cookson, V., Lesur, A., Eiden, K., Bernardin, F., Vallin, K. S. A., Borhade, S., Long, M., Ghahe, E. K., Jiménez-Alonso, J. J., Jemth, A. S., Loseva, O., Mortusewicz, O., Meyers, M., Viry, E., Johansson, A. I., & 14 others, 20 Apr 2023, In: Nature Metabolism. 5, 4, p. 642-659 18 p.
Research output: Contribution to journal › Article › Research › peer-reviewOpen Access1 Citation (Scopus)