Projects per year
Malignant transformation of cells goes along with profound metabolic rewiring to cope with increasing biomass and energy demands. The goal of our research is to understand these metabolic changes pinpointing metabolic bottlenecks that are specific to cancer cells and which, ultimately, might become effective targets for clinical oncotherapy.
To measure the dynamics of cellular metabolism, we make use of stable-isotope tracers and high-resolution Mass Spectrometry. Applying these key tools with molecular and cell biology approaches allows a functional and mechanistic understanding of how metabolism impacts cancer cell proliferation, survival and dissemination. A particular focus resides at understanding the metabolic processes that allow cancer cell motility and invasion, a process essential for the onset of the metastatic cascade. Indeed, metastasis is accountable for 90 % of all cancer deaths. Yet, it remains one of the biggest challenges in cancer therapy and is currently seen as incurable.
An example of our work includes the study of a phenomenon known as “formate overflow”, a metabolic pathway which we have identified to influence cell motility and metastasis.
An additional area of interest is the interaction of cancer cells with their environment. Our work in this respect focuses on immune cells, as they play an important role in shaping either a tumour-promoting or -suppressive environment. Since metabolism plays an important role during immune cell activation, we aim to understand these metabolic dependencies and seek alternative immune cell-dependent entry points to target cancer cells.
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I2TRON Kim Eiden: The role of mitochondrial folate metabolism during macrophage polarization (Mac1L)
Meiser, J. & Eiden, K.
15/10/21 → 14/10/25
Meiser, J. & Grünewald, A.
1/09/20 → 31/08/23
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasisKiweler, N., Delbrouck, C., Pozdeev, V. I., Neises, L., Soriano-Baguet, L., Eiden, K., Xian, F., Benzarti, M., Haase, L., Koncina, E., Schmoetten, M., Jaeger, C., Noman, M. Z., Vazquez, A., Janji, B., Dittmar, G., Brenner, D., Letellier, E. & Meiser, J., 16 May 2022, In: Nature Communications. 13, 1, p. 2699
Research output: Contribution to journal › Article › peer-reviewOpen Access
Fritah, S., Vogt Weisenhorn, D. M., Gomez Giro, G., Grusdat, M., Baron, A., Guerin, C., Franchina, D. G., Léonard, C., Domingues, O., Delhalle, S., Wurst, W. & 10 others, , May 2022, In: Nature Metabolism. 4, 5, p. 589-607 19 p.
Research output: Contribution to journal › Article › peer-review
Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stressBonagas, N., Gustafsson, N. M. S., Henriksson, M., Marttila, P., Gustafsson, R., Wiita, E., Borhade, S., Green, A. C., Vallin, K. S. A., Sarno, A., Svensson, R., Göktürk, C., Pham, T., Jemth, A. S., Loseva, O., Cookson, V., Kiweler, N., Sandberg, L., Rasti, A., Unterlass, J. E. & 48 others, , Feb 2022, In: Nature Cancer. 3, 2, p. 156-172 17 p.
Research output: Contribution to journal › Article › peer-reviewOpen Access2 Citations (Scopus)