Projects per year
Organisation profile
Organisation profile
Cancer metabolism:
Malignant transformation of cells goes along with profound metabolic rewiring to cope with increasing biomass and energy demands. The goal of our research is to understand these metabolic changes pinpointing metabolic bottlenecks that are specific to cancer cells and which, ultimately, might become effective targets for clinical oncotherapy.
To measure the dynamics of cellular metabolism, we make use of stable-isotope tracers and high-resolution Mass Spectrometry. Applying these key tools with molecular and cell biology approaches allows a functional and mechanistic understanding of how metabolism impacts cancer cell proliferation, survival and dissemination. A particular focus resides at understanding the metabolic processes that allow cancer cell motility and invasion, a process essential for the onset of the metastatic cascade. Indeed, metastasis is accountable for 90 % of all cancer deaths. Yet, it remains one of the biggest challenges in cancer therapy and is currently seen as incurable.
An example of our work includes the study of a phenomenon known as “formate overflow”, a metabolic pathway which we have identified to influence cell motility and metastasis.
Tumour environment:
An additional area of interest is the interaction of cancer cells with their environment. Our work in this respect focuses on immune cells, as they play an important role in shaping either a tumour-promoting or -suppressive environment. Since metabolism plays an important role during immune cell activation, we aim to understand these metabolic dependencies and seek alternative immune cell-dependent entry points to target cancer cells.
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Collaborations and top research areas from the last five years
Profiles
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IMMUNOGENCODE: Decoding the impact of germline and somatic genetic variation on anti-tumoral immunity and immunotherapy efficacy in brain metastatic tumors
Álvarez-Prado, Á. (PI) & Meiser, J. (Scientific Advisor/Mentor)
FNR - Fonds National de la Recherche
15/01/25 → 14/07/30
Project: Research
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Postdoctoral Fellowship: Metabolic targeting of cancer metastasis
Kiweler, N. (PI) & Meiser, J. (Scientific Advisor/Mentor)
The European Association for Cancer Research
5/10/24 → 5/10/27
Project: Research
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4M8: Formate-dependent Regulation of Cancer Metastasis
Meiser, J. (PI), Martinez Ruiz, L. (Partner), Manchon, E. (Partner) & Dahlhaus, A. (PhD Student)
1/05/24 → 30/04/29
Project: Research
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Calcium-mediated mitochondrial energy deficiency in Parkinson's and Alzheimer's diseases: Insights from computational modelling
Voorsluijs, V. & Skupin, A., Mar 2025, In: Current Opinion in Systems Biology. 40, 10 p., 100539.Research output: Contribution to journal › Review article › peer-review
Open Access -
Ketogenic diet suppresses colorectal cancer through the gut microbiome long chain fatty acid stearate
Tsenkova, M., Brauer, M., Pozdeev, V. I., Kasakin, M., Busi, S. B., Schmoetten, M., Cheung, D., Meyers, M., Rodriguez, F., Gaigneaux, A., Koncina, E., Gilson, C., Schlicker, L., Herebian, D., Schmitz, M., de Nies, L., Mayatepek, E., Haan, S., de Beaufort, C. & Cramer, T. & 4 others, , 20 Feb 2025, In: Nature Communications. 16, 1, 16 p., 1792.Research output: Contribution to journal › Article › Research › peer-review
Open Access1 Citation (Scopus) -
PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle
Benzarti, M., Neises, L., Oudin, A., Krötz, C., Viry, E., Gargiulo, E., Pulido, C., Schmoetten, M., Pozdeev, V., Lorenz, N. I., Ronellenfitsch, M. W., Sumpton, D., Warmoes, M., Jaeger, C., Lesur, A., Becker, B., Moussay, E., Paggetti, J., Niclou, S. P. & Letellier, E. & 1 others, , 26 Mar 2024, In: Cell Reports. 43, 3, 113868.Research output: Contribution to journal › Article › Research › peer-review
Open Access5 Citations (Scopus)